2024

Bcl-xL targeting eliminates ageing tumor-promoting neutrophils and inhibits lung tumor growth

Anita Bodac, Abdullah Mayet, Sarika Rana, Justine Pascual, Amber D Bowler, Vincent Roh, Nadine Fournier, Ligia Craciun, Pieter Demetter, Freddy Radkte, Etienne Meylan
EMBO Molecular Medicine (2024). Vol., num. , p. 1-27 DOI : https://doi.org/10.1038/s44321-023-00013-x

2023

Inhaled dry powder cisplatin increases antitumour response to anti-PD1 in a murine lung cancer model

Tamara Davenne, Pauline Percier, Lionel Larbanoix, Muriel Moser, Oberdan Leo, Etienne Meylan, Stanislas Goriely, Pierre Gérard, Nathalie Wauthoz, Sophie Laurent, Karim Amighi, Rémi Rosière
Journal of Controlled Release (2023). Vol.353, num. , p. 317-326 DOI : https://doi.org/10.1016/j.jconrel.2022.11.055

2022

Activin-A impairs CD8 T cell-mediated immunity and immune checkpoint therapy response in melanoma

Katarina Pinjusic, Olivier Andreas Dubey, Olga Egorova, Sina Nassiri, Etienne Meylan, Julien Faget, Daniel Beat Constam
Journal for ImmunoTherapy of Cancer (2022). Vol.10, num. 5, p. DOI : 10.1136/jitc-2022-004533

Neutrophil phenotypes and functions in cancer: A consensus statement

Daniel F. Quail, Borko Amulic, Monowar Aziz, Betsy J. Barnes, Evgeniy Eruslanov, Zvi G. Fridlender, Helen S. Goodridge, Zvi Granot, Andrés Hidalgo, Anna Huttenlocher, Mariana J. Kaplan, Ilaria Malanchi, Taha Merghoub, Etienne Meylan, Vivek Mittal, Mikael J. Pittet, Andrea Rubio-Ponce, Karin E. de Visser, Mikala Egeblad, Paul Kubes
Journal of Experimental Medicine (2022). Vol.219, num. 6, p. DOI : 10.1084/jem.20220011

2021

Neutrophil metabolism in the cancer context

Anita Bodac, Etienne Meylan, Tamara Davenne, Pauline Percier, Lionel Larbanoix, Muriel Moser, Oberdan Leo, Etienne Meylan, Stanislas Goriely, Pierre Gérard, Nathalie Wauthoz, Sophie Laurent, Karim Amighi, Rémi Rosière, Tamara Davenne, Pauline Percier, Lionel Larbanoix, Muriel Moser, Oberdan Leo, Etienne Meylan, Stanislas Goriely, Pierre Gérard, Nathalie Wauthoz, Sophie Laurent, Karim Amighi, Rémi Rosière
Seminars in Immunology (2021). Vol., num. , p. DOI : 10.1016/j.smim.2021.101583

Overcoming microenvironmental resistance to anti-PD-1 immunotherapy in lung cancer models

Amaia Martinez-Usatorre, Ece Kadioglu, Gael Boivin, Chiara Cianciaruso, Alan Guichard, Bruno Torchia, Nadine Zangger, Sina Nassiri, Ioanna Keklikoglou, Martina Schmittnaegel, Carola H. Ries, Etienne Meylan, Michele De Palma
Science Translational Medicine (2021). Vol.13, num. 606, p. DOI : 10.1126/scitranslmed.abd1616

Neutrophils in the era of cancer immune checkpoint blockade

Julien Faget, Solange Peters, Xavier Quantin, Etienne Meylan, Nathalie Bonnefoy
Journal for ImmunoTherapy of Cancer (2021). Vol.9, num. 7, p. DOI : 10.1136/jitc-2020-002242.

GLUT1 Expression in Tumor-Associated Neutrophils Promotes Lung Cancer Growth and Resistance to Radiotherapy

Pierre-Benoit Ancey, Caroline Contat, Gael Boivin, Silvia Sabatino, Justine Pascual, Nadine Zangger, Jean Yannis Perentes, Solange Peters, E Dale Abel, David G. Kirsch, Jeffrey C Rathmell, Marie-Catherine Vozenin, Etienne Meylan
Cancer Research (2021). Vol.81, num. , p. 2345–57 DOI : 10.1158/0008-5472.CAN-20-2870

Anti-Ly6G binding and trafficking mediate positive neutrophil selection to unleash the anti-tumor efficacy of radiation therapy

Gael Boivin, Pierre-Benoit Ancey, Romain Vuillefroy de Silly, Pradeep Kalambaden, Caroline Contat, Benoit Petit, Jonathan Ollivier, Jean Bourhis, Etienne Meylan, Marie-Catherine Vozenin
Oncoimmunology (2021). Vol.10, num. 1, p. 1876597 DOI : 10.1080/2162402X.2021.1876597.

2020

Low-dose photodynamic therapy promotes a cytotoxic immunological response in a murine model of pleural mesothelioma

Sabrina Cavin, Aspasia Gkasti, Julien Faget, Yameng Hao, Igor Letovanec, Maxime Reichenbach, Michel Gonzalez, Thorsten Krueger, Paul J Dyson, Etienne Meylan, Jean Yannis Perentes
European Journal Of Cardio-Thoracic Surgery (2020). Vol.58, num. 4, p. 783-791 DOI : 10.1093/ejcts/ezaa145.

Tumor-Promoting Ly-6G(+) SiglecF(high) Cells Are Mature and Long-Lived Neutrophils

Christina Pfirschke, Camilla Engblom, Jeremy Gungabeesoon, Yunkang Lin, Steffen Rickelt, Rapolas Zilionis, Marius Messemaker, Marie Siwicki, Genevieve M. Gerhard, Anna Kohl, Etienne Meylan, Ralph Weissleder, Allon M. Klein, Mikael J. Pittet
Cell Reports (2020). Vol.32, num. 12, p. 108164 DOI : 10.1016/j.celrep.2020.108164.

Combined deletion of Glut1 and Glut3 impairs lung adenocarcinoma growth

Caroline Contat, Pierre-Benoit Ancey, Nadine Zangger, Silvia Sabatino, Justine Pascual, Stéphane Escrig, Louise Jensen, Christine Goepfert, Bernard Lanz, Mario Lepore, Rolf Gruetter, Anouk Rossier, Sabina Berezowska, Christina Neppl, Inti Zlobec, Stéphanie Clerc-Rosset, Graham William Knott, Jeffrey C Rathmell, E Dale Abel, Anders Meibom, Etienne Meylan
Elife (2020). Vol.9, num. , p. e53618 DOI : 10.7554/eLife.53618

Durable and controlled depletion of neutrophils in mice

Gael Boivin, Julien Faget, Pierre-Benoit Ancey, Aspasia Gkasti, Julie Mussard, Camilla Engblom, Christina Pfirschke, Caroline Contat, Justine Pascual, Jessica Vazquez, Nathalie Bendriss-Vermare, Christophe Caux, Marie-Catherine Vozenin, Mikael J. Pittet, Matthias Gunzer, Etienne Meylan
(2020). Vol.11, num. 1, p. 2762 DOI : 10.1038/s41467-020-16596-9

CD36-mediated metabolic adaptation supports regulatory T cell survival and function in tumors

Haiping Wang, Fabien Franco, Yao-Chen Tsui, Xin Xie, Marcel P. Trefny, Roberta Zappasodi, Syed Raza Mohmood, Juan Fernández-García, Chin-Hsien Tsai, Isabell Schulze, Florence Picard, Etienne Meylan, Roy Silverstein, Ira Goldberg, Sarah-Maria Fendt, Jedd D. Wolchok, Taha Merghoub, Camilla Jandus, Alfred Zippelius, Ping-Chih Ho
Nature Immunology (2020). Vol., num. 21, p. 298–308. DOI : 10.1038/s41590-019-0589-5.

2019

Tumour exosomal CEMIP protein promotes cancer cell colonization in brain metastasis

Gonçalo Rodrigues, Ayuko Hoshino, Candia M. Kenific, Irina R. Matei, Loïc Steiner, Daniela Freitas, Han Sang Kim, Peter R. Oxley, Ilana Scandariato, Irene Casanova-Salas, Jinxiang Dai, Chaitanya R. Badwe, Brunilde Gril, Milica Tešić Mark, Brian D. Dill, Henrik Molina, Haiying Zhang, Alberto Benito-Martin, Linda Bojmar, Yonathan Ararso, Katharine Offer
Nature Cell Biology (2019). Vol.21, num. 11, p. 1403-+. DOI : 10.1038/s41556-019-0404-4.

2018

RANKL Signaling Sustains Primary Tumor Growth in Genetically Engineered Mouse Models of Lung Adenocarcinoma

Julien Faget, Caroline Contat, Nadine Zangger, Solange Peters, Etienne Meylan
Journal of Thoracic Oncology (2018). Vol.13, num. 3, p. 387-398 DOI : 10.1016/j.jtho.2017.11.121.

Glucose transporters in cancer – from tumor cells to the tumor microenvironment

Pierre-Benoit Ancey, Caroline Contat, Etienne Meylan
Febs Journal (2018). Vol.285, num. 16, p. 2926-2943. DOI : 10.1111/febs.14577.

Cellular Composition and Contribution of Tertiary Lymphoid Structures to Tumor Immune Infiltration and Modulation by Radiation Therapy

Gael Boivin, Pradeep Kalambaden, Julien Faget, Sylvie Rusakiewicz, Pierre Montay-Gruel, Etienne Meylan, Jean Bourhis, Guy Lesec, Marie-Catherine Vozenin
Frontiers in Oncology (2018). Vol.8, num. , p. DOI : 10.3389/fonc.2018.00256.

Snail mediates repression of the Dlk1-Dio3 locus in lung tumor-infiltrating immune cells

Svenja Groeneveld, Julien Faget, Nadine Zangger, Etienne Meylan
Oncotarget (2018). Vol.9, num. 64, p. 32331-32345. DOI : 10.18632/oncotarget.25965.

2017

RIP4 inhibits STAT3 signaling to sustain lung adenocarcinoma differentiation

Jawahar Kopparam, Johanna Chiffelle, Paolo Angelino, Alessandra Piersigilli, Nadine Zangger, Mauro Delorenzi, Etienne Meylan
Cell death and differentiation (2017). Vol., num. , p. DOI : 10.1038/cdd.2017.81.

RIP off STAT3 to counteract tumor progression

Jawahar Kopparam, Etienne Meylan
Cell Cycle (2017). Vol., num. , p. 1-2 DOI : 10.1080/15384101.2017.1360643.

Mutant CTNNB1 and histological heterogeneity define metabolic subtypes of hepatoblastoma

Stefania Crippa, Pierre-Benoit Ancey, Jessica Vazquez, Paolo Angelino, Anne-Laure Rougemont, Catherine Guettier, Vincent Zoete, Mauro Delorenzi, Olivier Michielin, Etienne Meylan
EMBO Molecular Medicine (2017). Vol., num. , p. e201707814 DOI : 10.15252/emmm.201707814.

Osteoblasts remotely supply lung tumors with cancer-promoting SiglecF(high) neutrophils

Camilla Engblom, Christina Pfirschke, Rapolas Zilionis, Janaina Da Silva Martins, Stijn A. Bos, Gabriel Courties, Steffen Rickelt, Nicolas Severe, Ninib Baryawno, Julien Faget, Virginia Savova, David Zemmour, Jaclyn Kline, Marie Siwicki, Christopher Garris, Ferdinando Pucci, Hsin-Wei Liao, Yi-Jang Lin, Andita Newton, Omar K. Yaghi, Yoshiko Iwamoto
Science (2017). Vol.358, num. 6367, p. 1147-+. DOI : 10.1126/science.aal5081.

Neutrophils and Snail Orchestrate the Establishment of a Pro-tumor Microenvironment in Lung Cancer

Julien Faget, Svenja Groeneveld, Gael Boivin, Martial Sankar, Nadine Zangger, Miguel Garcia, Nicolas Guex, Inti Zlobec, Loïc Steiner, Alessandra Piersigilli, Ioannis Xenarios, Etienne Meylan
Cell Reports (2017). Vol.21, num. 11, p. 3190-3204. DOI : 10.1016/j.celrep.2017.11.052.

2014

GLUT3 is induced during epithelial-mesenchymal transition and promotes tumor cell proliferation in non-small cell lung cancer

Mark Masin, Jessica Vazquez, Simona Rossi, Svenja Groeneveld, Natasha Samson, Petra C Schwalie, Bart Deplancke, Laura E Frawley, Jérôme Gouttenoire, Darius Moradpour, Trudy G. Oliver, Etienne Meylan
Cancer & metabolism (2014). Vol.2, num. , p. 11 DOI : 10.1186/2049-3002-2-11.

2013

Targeting receptor activator of nuclear factor-kappa B as a new therapy for bone metastasis in non-small cell lung cancer

Solange Peters, Etienne Meylan
Current Opinion In Oncology (2013). Vol.25, num. 2, p. 137-144 DOI : DOI : 10.1097/CCO.0b013e32835d720b.

2012

Regulation of Monocyte Functional Heterogeneity by miR-146a and Relb

Martin Etzrodt, Virna Cortez-Retamozo, Andita Newton, Jimmy Zhao, Aylwin Ng, Moritz Wildgruber, Pedro Romero, Thomas Wurdinger, Ramnik Xavier, Frederic Geissmann, Etienne Meylan, Matthias Nahrendorf, Filip K. Swirski, David Baltimore, Ralph Weissleder, Mikael J. Pittet
Cell Reports (2012). Vol.1, num. 4, p. 317-324 DOI : 10.1016/j.celrep.2012.02.009.

2011

Nonstructural protein 3-4A: the Swiss army knife of hepatitis C virus

K. Morikawa, C. M. Lange, Jérôme Gouttenoire, Etienne Meylan, V. Brass, F. Penin, Darius Moradpour
Journal of viral hepatitis (2011). Vol.18, num. 5, p. 305-15 DOI : 10.1111/j.1365-2893.2011.01451.x.

Caspase-2-mediated cleavage of Mdm2 creates a p53-induced positive feedback loop

Trudy G. Oliver, Etienne Meylan, Gregory P. Chang, Wen Xue, James R. Burke, Timothy J. Humpton, Diana Hubbard, Arjun Bhutkar, Tyler Jacks
Molecular cell (2011). Vol.43, num. 1, p. 57-71 DOI : 10.1016/j.molcel.2011.06.012.

Response and resistance to NF-κB inhibitors in mouse models of lung adenocarcinoma

Wen Xue, Etienne Meylan, Trudy G. Oliver, David M. Feldser, Monte M. Winslow, Roderick Bronson, Tyler Jacks
Cancer discovery (2011). Vol.1, num. 3, p. 236-247 DOI : 10.1158/2159-8290.CD-11-0073.

2010

Cleavage of mitochondrial antiviral signaling protein in the liver of patients with chronic hepatitis C correlates with a reduced activation of the endogenous interferon system

Pantxika Bellecave, Magdalena Sarasin-Filipowicz, Olivier Donzé, Audrey Kennel, Jérôme Gouttenoire, Etienne Meylan, Luigi Terracciano, Jürg Tschopp, Christoph Sarrazin, Thomas Berg, Darius Moradpour, Markus H. Heim
Hepatology (Baltimore, Md.) (2010). Vol.51, num. 4, p. 1127-36. DOI : 10.1002/hep.23426.

2009

DAI/ZBP1 recruits RIP1 and RIP3 through RIP homotypic interaction motifs to activate NF‐κB

Manuele Rebsamen, Leonhard X Heinz, Etienne Meylan, Marie-Cécile Michallet, Kate Schroder, Kay Hofmann, Jessica Vazquez, Chris A Benedict, Jürg Tschopp
EMBO Reports (2009). Vol.10, num. 8, p. 916-22 DOI : 10.1038/embor.2009.109.

Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1

David A Barbie, Pablo Tamayo, Jesse S. Boehm, So Young Kim, Susan E. Moody, Ian F. Dunn, Anna C. Schinzel, Peter Sandy, Etienne Meylan, Claudia Scholl, Stefan Fröhling, Edmond M. Chan, Martin L. Sos, Kathrin Michel, Craig Mermel, Serena J. Silver, Barbara A. Weir, Jan H. Reiling, Qing Sheng, Piyush B. Gupta, Raymond C. Wadlow
Nature (2009). Vol.462, num. 7269, p. 108-12 DOI : 10.1038/nature08460.

Requirement for NF-kappaB signalling in a mouse model of lung adenocarcinoma

Etienne Meylan, Alison L. Dooley, David M. Feldser, Lynn Shen, Erin Turk, Chensi Ouyang, Tyler Jacks
Nature (2009). Vol.462, num. 7269, p. 104-7 DOI : 10.1038/nature08462.

2008

Intracellular pattern-recognition receptors

Catherine Dostert, Etienne Meylan, Jürg Tschopp
Advanced drug delivery reviews (2008). Vol.60, num. 7, p. 830-40. DOI : 10.1016/j.addr.2007.12.003.

NLRX1: friend or foe?

Etienne Meylan, Jürg Tschopp
EMBO Reports (2008). Vol.9, num. 3, p. 243-5. DOI : 10.1038/embor.2008.23.

TRADD Protein Is an Essential Component of the RIG-like Helicase Antiviral Pathway

Marie-Cécile Michallet, Etienne Meylan, Maria A. Ermolaeva, Jessica Vazquez, Manuele Rebsamen, Joseph Curran, Hendrik Poeck, Michael Bscheider, Gunther Hartmann, Martin König, Ulrich Kalinke, Manolis Pasparakis, Jürg Tschopp
Immunity (2008). Vol.28, num. 5, p. 651-61. DOI : 10.1016/j.immuni.2008.03.013.

IRAK2 takes its place in TLR signaling

Etienne Meylan, Jürg Tschopp
Nature Immunology (2008). Vol.9, num. 6, p. 581-2. DOI : 10.1038/ni0608-581.

The antiviral adaptor proteins Cardif and Trif are processed and inactivated by caspases

Manuele Rebsamen, Etienne Meylan, Joseph Curran, Jürg Tschopp
Cell death and differentiation (2008). Vol.15, num. 11, p. 1804-11 DOI : 10.1038/cdd.2008.119.

2006

Toll-Like Receptors and RNA Helicases: Two Parallel Ways to Trigger Antiviral Responses

Etienne Meylan, Jürg Tschopp
Molecular cell (2006). Vol.22, num. 5, p. 561-9. DOI : 10.1016/j.molcel.2006.05.012.

Intracellular pattern recognition receptors in the host response

Etienne Meylan, Jürg Tschopp, Michael Karin
Nature (2006). Vol.442, num. 7098, p. 39-44 DOI : 10.1038/nature04946.

Intracellular Trafficking of Interleukin-1 Receptor I Requires Tollip

Brian Brissoni, Laetitia Agostini, Michel Kropf, Fabio Martinon, Valentin Swoboda, Saskia Lippens, Helen Everett, Natalia Aebi, Sophie Janssens, Etienne Meylan, Michela Ferlberbaum-Corti, Harald Hirling, Jean Gruenberg, Jürg Tschopp, Kimberly Burns
Current Biology (2006). Vol.16, num. 22, p. 2265-70. DOI : 10.1016/j.cub.2006.09.062.

2005

The RIP kinases: crucial integrators of cellular stress

Etienne Meylan, Jürg Tschopp
Trends in biochemical sciences (2005). Vol.30, num. 3, p. 151-9. DOI : 10.1016/j.tibs.2005.01.003.

Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus

Etienne Meylan, Joseph Curran, Kay Hofmann, Darius Moradpour, Marco Binder, Ralf Bartenschlager, Jürg Tschopp
Nature (2005). Vol.437, num. 7062, p. 1167-72 DOI : 10.1038/nature04193.

2004

Identification of bacterial muramyl dipeptide as activator of the NALP3/cryopyrin inflammasome

Fabio Martinon, Laetitia Agostini, Etienne Meylan, Jürg Tschopp
(2004). Vol.14, num. 21, p. 1929-1934 DOI : 10.1038/ni1061.

RIP1 is an essential mediator of Toll-like receptor 3–induced NF-κB activation

Etienne Meylan, Kimberly Burns, Kay Hofmann, Vincent Blancheteau, Fabio Martinon, Michelle Kelliher, Jürg Tschopp
(2004). Vol.5, num. 5, p. 503-7. DOI : 10.1038/ni1061.

2002

RIP4 (DIK/PKK), a novel member of the RIP kinase family, activates NF‐κB and is processed during apoptosis

Etienne Meylan, Fabio Martinon, Margot Thome, Michael Gschwendt, Jürg Tschopp
(2002). Vol.3, num. 12, p. 1201-8 DOI : 10.1093/kvf236.